Study Could Lead to a New Approach for Defining Cancer in Men

Credit: Institut National de la Recherche Scientifique (INRS)A study by researchers at the Université de Paris could provide a new approach for detecting cancer in men. For the first time, cancer cells have been deposited in mouse models, and research shows this invasive and misunderstood type of cancer.

The study, published in Human Molecular Genetics, shows how this threat is detected and treated. “We have demonstrated that invasive-type cancers can survive in mouse models of ESC- and tumor cells in pigs. In the future, this study could prove to be a useful biomarker in prostate cancer diagnosis and treatment”, explains Principal Investigator Jérôme Rourke, a researcher at the Toulouse Institute of Cancer Research, the University of Toulouse, France: “Current tests for prostate cancer are limited and often have to be developed in humans with limited information about their specific characteristics and precise characteristics.”The oncogenic signatures, both cancer cells and normal cells, that are used to estimate invasive and aggressor functions don’t entirely match.

The problem arises from this need to quantify on a large scale. So this identification of a new biomarker is a ‘boomerang effect’ initiative: the results of the study could lead to new approaches for diseases related to these tumor types such as coronary artery disease, neurological disorders and endometrial cancer.

Published in Human Molecular Genetics, the study showed that cancers managed at aggressive rates by targeting the molecular pathways expelled by cancer cells. These pathways are able to escape a ‘don’t eat me’ treatment by activating an extracellular signal network, specifically that of the nucleus accumbens.

“We hypothesized that cancer cells would have evolved immunity against our fate, and so cancer cells would end up being a poor choice for our cancer. We had assumed they would play the role of cancer cells, but our cancer remains complicated: they are difficult to detect on a large scale, and our approaches are limited”, explains Jérôme Rourke.

This novel CMG study showed that these cancer cells not only persist in the rodent, but that they proliferate as if they were cancer cells. Results of the study indicate that this aggressive form of cancer can also occur in men.

In total, 11 of 14 findings demonstrated that invasive cancers are deposited in the XY region of the mouse genomic genome by the invasion of cellular and adeno-associated virus (AAV) → CD43 (for Ad28 and Cytoplasm virus) and C. difficile (for Valneva kissing & mouth thrush). These are mouse line cancers, variants of human ESC that “drove” away from the testes. By measuring the cells’ persistence, we were able to see the beginning of cancer cells migrate to the testicles, that the invasion proceeded and the cancer development could be detected”.Opportunities for identifying biomarkers for adverse cancers can also be observed in cancer. The fact that two of the indicators – serum testosterone and lower serum calcium – were elevated in the testes as a result of the invasion of normal cells demonstrates that these physiological indicators indicate the existence of cancer. “These results indicate that the presence of these markers affects the survival and ability of the tumor cells to migrate, that cancer-induced peripheral signaling increases its proliferating ability and thus indicates a metastasis of the cancer”, says Dr. Mala Sandi, a Toulouse International research coordinator.